Innovation is one of the major factors affecting the competitiveness of enterprises, regions and national economies. The effects of science, research and innovation at regional level increase the socio-economic growth of the regions and contribute to the removal of regional disparities. The European Union considers the growth of their innovation performance as a key factor in the overall development of the regions, which, with multiplier effects, is reflected in the socio-economic development of the regions. The aim of the article is to evaluate the innovation performance of regions of the Visegrad Group putting a stress on human capital. The basic method used in the processing of matter is descriptive statistics and quantitative comparative analysis. The survey will be carried out at the level of NUTS II regions. Data sources for problem processing are indicators internationally monitored through a regional innovation index, which is reported by the European Commission. Previous studies and assessments show that V4 countries are lagging behind European leaders in innovation performance; they belong to the group of "moderate innovators". In Visegrad Group countries, the highest innovation performance is reported by the capital regions.
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